Tag Archives: cell biology

Find the fun in immunology

To build appreciation for the science of immunology, we need to find the fun in it.

Many thousands of people spend their lives in windowless laboratories, standing day in and day out, barely speaking to their silent lab mates, often working in a 4°C room, or holding their arms up for hours while they conduct their experiments inside the awkward, but sterile cell culture hood.

Why are they doing this?

They are immunologists. Immunologists address the problems of the immune system that their fellow humans have to live with, like Leukemia, AIDS, allergies and autoimmune disorders. Immunologists use biochemistry, cell biology, molecular biology and genetics to look for ways to help patients and prevent disease.

So, we could simply say that these immunologists are serving their fellow man. But their motivation is not simply to help mankind. Something else drives them to spend those days in a tissue culture hood counting thousands of white blood cells.

Why did these immunologists take the lab path? Why didn’t they become social workers, firemen or even medical doctors? Well, I’ll tell you. Immunology is fun. Immunology involves watching cells identify and destroy other cells. These cells appear to be very similar to every other cell in the universe. These cells have outer membranes, nuclei, DNA and proteins that are almost indistinguishable from every other cell.

The questions are why this particular cell kills bacteria. Why doesn’t this cell kill all types of bacteria? Why does this cell in some people, not kill bacteria? The answers involve making endless comparisons between healthy and sick patients, between pathogenic and non-pathogenic bacteria, between humans and mice and between mice and flies.

So, Immunology is a puzzle. How does the puzzle work? We collect up as many clues as we can, we make a guess, we do an experiment and we try to figure out whether our idea was correct. We compare what we thought would happen to what did happen.

We have tools we can use. And we have rules for addressing these puzzles. We have several paths that others have taken before us that guide our way: We have biochemistry, cell biology, genetics, chemistry and physics. Each of these paths have their own rules and their own tools.

If you could jump in and try out these tools, and attempt a few of the puzzles yourself, then you would understand how immunology works. You would experience the fun! This is what we are doing with Immune Attack 2.0: we are letting you play Immunology… without the hours of standing in a windowless lab.

Students at Shadow Mountain High School, Phoenix, AZ Recommend Immune Attack

Wonder whether your students will like Immune Attack? Wonder whether it is game enough to hold their attention? Well watch this video.

And oh, if you work for a AAA video game company you can reach me by email!

Thank you to Debbie Kovesdy, her students and the biology teachers who participated in our evaluation. If YOU would like your students to participate in our evaluation, please let me know! We need more students to strengthen our data… We have significant gains in LEARNING and CONFIDENCE. Be a part of a revolution in learning and in gaming!

Register here!!!!

Making science video games: Spore and the misrepresentation of science.

A friend said to me,
“I am trying to make a video game to create interest in engineering.  Someone told me Spore taught a lot about evolution.  What do you think?”

I did play Spore and I was very disappointed.  I was angry, actually, because the things that are so cool about evolution were not present.  Playing Spore was like expecting an excellent new baseball game and instead it was a soccer game.  The worst part is, that real evolution would make a great game!

The real problem with Spore was that Maxis and EA advertised it as being about evolution, and bragged about it being a real science video game.  However, anyone who knows about evolution knows that isn’t true. The problem is that so many people do not know how evolution actually works, and could easily be confused by the version of “evolution” presented in Spore.

Science journalist John Bohannon assembled a team of scientists to give Spore a report card on all the subjects its claimed to present.  You can see this report card here: http://scienceguild.org/wiki/index.php?title=Spore You can read John’s review of Spore in Science Magazine, here:  http://www.sciencemag.org/content/322/5901/531.3.full

Why am I writing about it?  Because science can be explained by playing games, but only when the core of the science must be used to win the game.  For example, a game about evolution should require the player to overcome that fact that random events may wipe out your offspring at any moment.  That would be exciting and teach real science.  I am writing about this because we (learning technology folks) are still struggling with this concept.  I believe we have learned the theory: we know we want a game that requires the player to use real science to win.  The struggling is coming from the question, how do we make that game?   Working closely with the scientist, or having the scientist be the game writer is the answer.  For examples, see Metablast, Cellcraft and Surge (and Immune Attack, of course).

Immune Attack in the press.

Cell Article on Video games 2010

Amy Maxmen wrote an article about Immune Attack for Cell!  Maxmen keeps you up to date about the push from the President and First Lady to make sure we are using video games and all learning technology to their fullest potential.   And then Maxmen summaries what scientists think of video game about science and then what DATA there is suggesting that they work!

The data that is quoted in this article will be published this fall semester.  We are in the final round of evaluations this semester.

Cellcraft puts you in the driver seat of a cell

So, how do cells avoid viruses? If you wonder, try playing the game CellCraft.  It is a terrific game for middle school students or anyone.   Check it out, give the Cellcraft team some props on their forum, and then tell me what you like about the game.


www.kongregate.com Play Cellcraft here!

Immune Attack address more molecular detail, but we are trying to do essentially the same thing: teach people how cells actually operate at the molecular level.  The world of the Cell is frankly a fascinating huge place and it should be explored in as many ways as possible, games, stories, videos, it is a rich place for storytelling with many many points of conflict… between cells and viruses, human cells and bacteria, DNA vs damaging radicals…There are endless stories to tell!

Congratulations to the Cell Craft Team!  And thank you!